{"id":139,"date":"2020-03-21T01:06:55","date_gmt":"2020-03-21T04:06:55","guid":{"rendered":"https:\/\/www.blogs.unicamp.br\/covid-19\/?p=139"},"modified":"2020-05-12T20:55:26","modified_gmt":"2020-05-12T23:55:26","slug":"quimica-do-coronavirus-parte-i","status":"publish","type":"post","link":"https:\/\/www.blogs.unicamp.br\/covid-19\/quimica-do-coronavirus-parte-i\/","title":{"rendered":"Qu\u00edmica do Coronav\u00edrus – Parte I"},"content":{"rendered":"\t\t
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\u00c0 luz do atual surto de um novo coronav\u00edrus (COVID-19), o Blog Quimikinha<\/strong> gostaria de compartilhar um breve hist\u00f3rico sobre a fam\u00edlia coronav\u00edrus e sua estrutura macrosc\u00f3pica (parte I), destacando uma importante prote\u00edna que est\u00e1 envolvida no processo de infec\u00e7\u00e3o viral (parte II). Por \u00faltimo, vamos falar sobre pesquisa e desenvolvimento de agentes terap\u00eauticos e vacinas para COVID-19 e doen\u00e7as relacionadas ao coronav\u00edrus humano (parte III). Esta postagem tem como objetivo fornecer uma breve vis\u00e3o geral das importantes contribui\u00e7\u00f5es da qu\u00edmica no desenvolvimento de f\u00e1rmacos para o tratamento do COVID-2019. Como sabemos, a qu\u00edmica tem um papel fundamental a desempenhar na compreens\u00e3o de tudo, desde a estrutura viral \u00e0 patog\u00eanese, isolamento de vacinas e terapias, bem como no desenvolvimento de materiais e t\u00e9cnicas utilizadas por pesquisadores, virologistas e m\u00e9dicos. (1)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Fam\u00edlia coronav\u00edrus <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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O coronav\u00edrus (CoV) \u00e9 uma grande fam\u00edlia de v\u00edrus que causam doen\u00e7as que variam do resfriado comum a doen\u00e7as mais graves. Em 11 de fevereiro de 2020, a Organiza\u00e7\u00e3o Mundial de Sa\u00fade nomeou a doen\u00e7a viral que se espalhou pelo mundo de novo coronav\u00edrus 2019 (COVID-19). (2) Isso porque j\u00e1 existiram outras esp\u00e9cies da mesma fam\u00edlia viral que infectaram humanos. Por exemplo, Em 2003, estava em circula\u00e7\u00e3o a S\u00edndrome Respirat\u00f3ria Aguda Grave (SARS-CoV). Atualmente, ainda temos em circula\u00e7\u00e3o a S\u00edndrome Respirat\u00f3ria do Oriente M\u00e9dio (MERS-CoV). No entanto, esse \u00faltimo v\u00edrus n\u00e3o se espalhou pelo mundo tal como o que causa a doen\u00e7a COVID-19 (SARS-CoV-2)<\/em>. Para saber um pouco mais sobre temas relacionados \u00e0 biologia molecular e curiosidade do coronav\u00edrus recomendo o conte\u00fado divulgado pela bi\u00f3loga Rafaela da Rosa Ribeiro que trabalha com o COVID-2019 na It\u00e1lia.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Estrutura b\u00e1sica do coronav\u00edrus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Na sua superf\u00edcie, o v\u00edrus cont\u00e9m importantes prote\u00ednas tal como \u00e9 mostrado no Video produzido pelo grupo Biosolution.\u00a0\u00a0Estas macromol\u00e9culas\u00a0<\/span>se encontram incorporadas na bicapa lip\u00eddica da superf\u00edcie do v\u00edrus. Dentre as macromol\u00e9culas, se destaca a prote\u00edna spike pelo sua forma de coroa que d\u00e1 o nome ao v\u00edrus e, sobretudo, pelo seu papel fundamental na infec\u00e7\u00e3o viral.\u00a0<\/span>O material gen\u00e9tico do v\u00edrus encontra-se no interior do nucleocaps\u00eddeo, um inv\u00f3lucro de natureza proteica.<\/p>

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No v\u00eddeo, encontra-se uma vis\u00e3o tridimensional do coronav\u00edrus destacando sua constitui\u00e7\u00e3o. Al\u00e9m disso, ele cont\u00e9m uma imagem do microsc\u00f3pio eletr\u00f4nico de transmiss\u00e3o que mostra o SARS-CoV-2, o v\u00edrus que causa o COVID-19, isolado de um paciente infectado.<\/span><\/p>\n

Na pr\u00f3xima postagem, vamos falar um pouco mais sobre como a estrutura da prote\u00edna spike do coronav\u00edrus<\/span> tem papel fundamental no processo de contamina\u00e7\u00e3o celular.<\/span><\/p>\n

Informem-se, cuidem-se e at\u00e9 logo!<\/span><\/p>\n

Prevenir \u00e9 sempre o melhor rem\u00e9dio!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Refer\u00eancias biliogr\u00e1ficas<\/span><\/b><\/p>

\u00a0<\/span><\/b>1.\u00a0 \u00a0 \u00a0Chemistry in Coronavirus Research: A Free to Read Collection from the American Chemical Society. Available from:\u00a0https:\/\/pubs.acs.org\/page\/vi\/chemistry_coronavirus_research#<\/a><\/span><\/p>

2. \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Liu W, Zhu H-L, Duan Y. Effective Chemicals against Novel Coronavirus (COVID-19) in China. Curr Top Med Chem. Available from:\u00a0http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32133962<\/a><\/p>

3. \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Structural view of coronavirus cell entry and neutralisation\u00a0 Available from:\u00a0http:\/\/www.esrf.eu\/UsersAndScience\/Publications\/Highlights\/2012\/sb\/sb7 \u00a0<\/a><\/span><\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Os argumentos expressos nos posts deste especial s\u00e3o dos pesquisadores, produzidos a partir de seus campos de pesquisa cient\u00edfica e atua\u00e7\u00e3o profissional e foi revisado por pares da mesma \u00e1rea t\u00e9cnica-cient\u00edfica da Unicamp.\nN\u00e3o, necessariamente, representam a vis\u00e3o da Unicamp. Essas opini\u00f5es n\u00e3o substituem conselhos m\u00e9dicos.\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\teditorial<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

\u00c0 luz do atual surto de um novo coronav\u00edrus (COVID-19), o Blog Quimikinha gostaria de compartilhar um breve hist\u00f3rico sobre a fam\u00edlia coronav\u00edrus e sua estrutura macrosc\u00f3pica (parte I), destacando uma importante prote\u00edna que est\u00e1 envolvida no processo de infec\u00e7\u00e3o viral (parte II). Por \u00faltimo, vamos falar sobre pesquisa e […]<\/p>\n","protected":false},"author":110,"featured_media":307,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"editor_plus_copied_stylings":"{}","pgc_sgb_lightbox_settings":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"categories":[32],"tags":[58,42,13,49,41],"class_list":["post-139","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-coronavirus","tag-corona","tag-coronovirus","tag-covid-19","tag-quimica","tag-virus"],"yoast_head":"\nQu\u00edmica do Coronav\u00edrus - Parte I - Especial COVID-19 | Blogs Unicamp<\/title>\n<meta name=\"description\" content=\"\u00daltimas postagens da rede de Blogs de Ci\u00eancias da Unicamp sobre o surto do novo coronavirus (2019-nCoV)\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.blogs.unicamp.br\/covid-19\/quimica-do-coronavirus-parte-i\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Qu\u00edmica do Coronav\u00edrus - 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