{"id":85,"date":"2008-06-04T19:58:00","date_gmt":"2008-06-04T22:58:00","guid":{"rendered":"http:\/\/scienceblogs.com.br\/eccemedicus\/2008\/06\/o-cerebro-humano\/"},"modified":"2008-06-04T19:58:00","modified_gmt":"2008-06-04T22:58:00","slug":"o-cerebro-humano","status":"publish","type":"post","link":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/2008\/06\/04\/o-cerebro-humano\/","title":{"rendered":"O C\u00e9rebro Humano"},"content":{"rendered":"<div><a href=\"http:\/\/www.hhmi.org\/research\/investigators\/figs\/images\/lahn_fig1_lg.gif\" data-rel=\"lightbox-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img decoding=\"async\" alt=\"\" src=\"http:\/\/www.hhmi.org\/research\/investigators\/figs\/images\/lahn_fig1_lg.gif\" border=\"0\" \/><\/a><span style=\"font-family:courier new;font-size:78%\"> Cover image, <i>Cell<\/i>, December 29, 2004; illustrator, Sean Gould. See also Dorus, S., Vallender, E.J., Evans, P.D., Anderson, J.R., Gilbert, S.L., Mahowald, M., Wyckoff, G.J., Malcom, C.M., and Lahn, B.T. 2004. <i>Cell<\/i> 119:1027\u20131040<\/span><\/div>\n<p>Ao ler um artigo sobre gen\u00e9tica evolucionista no <a href=\"http:\/\/www.amigodemontaigne.blogspot.com\/\">Amigo de Montaigne<\/a>, encontrei o <a href=\"http:\/\/www.hhmi.org\/research\/investigators\/lahn.html\">artigo<\/a> original de novembro de 2007, que cita o <span>paper<\/span> acima. Segue um trecho do texto de Bruce Lahn:<\/p>\n<p>&#8220;<span>Accelerated evolution of brain genes in the descent of humans<\/span>. To address whether the evolution of the human brain has left genome-wide genetic imprints, we systematically examined the evolutionary history of genes implicated in diverse biological aspects of brain function. This analysis showed that, on average, protein sequences of brain-related genes have evolved more rapidly in primates than in other mammalian taxa, and that this accelerated evolution is most dramatic along the lineage leading to humans. Moreover, when examining only the subset of genes that functions predominantly in brain development, the high rate of evolution in the human lineage becomes even more pronounced. <\/p>\n<p>The above results argue that the remarkable phenotypic evolution of the human brain is correlated with accelerated evolution in the protein-coding regions of the underlying genes, particularly those involved in brain development. These results also argue that the accelerated evolution, visible across many genes, likely reflects the accumulation of a large number of advantageous mutations scattered across many brain-related genes in the course of primate and human evolution.&#8221;<\/p>\n<p><span><span><span><span><\/span><\/span><\/span><\/span>O texto esbarra na teleologia c\u00f3smica a la Arist\u00f3teles. N\u00e3o fica claro pelo texto, a evolu\u00e7\u00e3o hist\u00f3rica dos genes relacionados ao advento do c\u00e9rebro humano. Saber se o aparecimento do c\u00e9rebro humano deixou pegadas gen\u00f4micas parece querer encarar o problema pelo avesso. Ficamos com a impress\u00e3o de que, devido ao um ac\u00famulo de um grande n\u00famero de muta\u00e7\u00f5es vantajosas, tivemos uma evolu\u00e7\u00e3o acelerada.<\/p>\n<p>Tais muta\u00e7\u00f5es s\u00e3o raras. N\u00e3o seria pertinente perguntar se tais genes j\u00e1 n\u00e3o estavam l\u00e1 e foram selecionados por algum fator que pressionou a evolu\u00e7\u00e3o dos homin\u00eddeos nessa dire\u00e7\u00e3o? Mostrar que temos genes para cabe\u00e7a grande n\u00e3o \u00e9 o mesmo que justificar nossa cabe\u00e7a grande. A hist\u00f3ria do aparecimento do fator que causou a sele\u00e7\u00e3o \u00e9, no meu modo de ver, a pergunta evolucion\u00e1ria.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cover image, Cell, December 29, 2004; illustrator, Sean Gould. See also Dorus, S., Vallender, E.J., Evans, P.D., Anderson, J.R., Gilbert, S.L., Mahowald, M., Wyckoff, G.J., Malcom, C.M., and Lahn, B.T. 2004. Cell 119:1027\u20131040 Ao ler um artigo sobre gen\u00e9tica evolucionista no Amigo de Montaigne, encontrei o artigo original de novembro de 2007, que cita o [&hellip;]<\/p>\n","protected":false},"author":466,"featured_media":86,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"pgc_sgb_lightbox_settings":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"categories":[12],"tags":[],"class_list":["post-85","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evolucao"],"_links":{"self":[{"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/posts\/85","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/users\/466"}],"replies":[{"embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/comments?post=85"}],"version-history":[{"count":0,"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/posts\/85\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/media\/86"}],"wp:attachment":[{"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/media?parent=85"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/categories?post=85"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/eccemedicus\/wp-json\/wp\/v2\/tags?post=85"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}