{"id":9248,"date":"2017-05-12T20:00:26","date_gmt":"2017-05-12T23:00:26","guid":{"rendered":"http:\/\/scienceblogs.com.br\/hypercubic\/?p=9248"},"modified":"2017-05-12T20:00:26","modified_gmt":"2017-05-12T23:00:26","slug":"o-lado-bom-do-lago-txico","status":"publish","type":"post","link":"https:\/\/www.blogs.unicamp.br\/hypercubic\/2017\/05\/o-lado-bom-do-lago-txico\/","title":{"rendered":"O lado bom do lago t\u00f3xico"},"content":{"rendered":"<h4 align=\"justify\"><img decoding=\"async\" src=\"https:\/\/sciencealert.com\/images\/articles\/processed\/Berkeley_Pit_1024.jpg\" \/><\/h4>\n<h4 align=\"justify\">H\u00e1 males que v\u00eam para o bem mas que bem poderia vir de um mal t\u00e3o grande quanto um lago t\u00f3xico numa mina abandonada? Resposta: novos e potentes antibi\u00f3ticos.<\/h4>\n<p align=\"justify\">Berkeley Pit \u00e9 uma mina de cobre a c\u00e9u aberto situada no interior de Montana, nos Estados Unidos. Abandonada desde 1982, a mina deu lugar a um lago com mais de 540 metros de profundidade, formado por \u00e1gua t\u00e3o \u00e1cida quanto uma limonada temperada com ars\u00eanico.<\/p>\n<p align=\"justify\">Como ningu\u00e9m mora ali perto, n\u00e3o h\u00e1 riscos para os humanos. Mas os animais selvagens t\u00eam menos sorte. Os gansos-da-neve \u00e0s vezes pousam ali para descansar de suas migra\u00e7\u00f5es ou se abrigar de tempestades. Nos \u00faltimos 20 anos, centenas dessas aves j\u00e1 morreram intoxicadas ao fazer um <em>pit stop<\/em> em <a href=\"https:\/\/en.wikipedia.org\/wiki\/Berkeley_Pit\">Berkeley Pit<\/a>. Em 1995, aut\u00f3psias de 342 gansos encontrados mortos no lago revelaram que eles foram consumidos por queimaduras e ulcera\u00e7\u00f5es causadas por altas concentra\u00e7\u00f5es de cobre, c\u00e1dmio e ars\u00eanico.<\/p>\n<p align=\"justify\">Nem todo mundo que cai nessa sopa met\u00e1lica se d\u00e1 mal. Nos \u00faltimos anos, os cientistas descobriram que Berkeley Pit \u00e9 um para\u00edso para algumas esp\u00e9cies de fungos e bact\u00e9rias extrem\u00f3filas. Entre os pesquisadores que estudam a \u00e1rea est\u00e3o os qu\u00edmicos Andrea A. Stierle e Donald B. Stierle, da Universidade de Montana. Esses dois irm\u00e3os est\u00e3o sempre analisando os compostos incomuns produzidos por esses micr\u00f3bios dur\u00f5es.<\/p>\n<p align=\"justify\">Depois de encontrar microorganismos capazes de sintetizar compostos anti-inflamat\u00f3rios, os dois Stierle resolveram ver o que aconteceria se cultivassem um par de fungos <em>Penicillium<\/em> (<em>P. fuscum e P. camembertii<\/em>) em laborat\u00f3rio. Seis dias mais tarde, eles descobriram que essas criaturinhas haviam se juntado para produzir novos compostos que nenhuma poderia fazer sozinha.<\/p>\n<p align=\"justify\"><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/pubs.acs.org\/appl\/literatum\/publisher\/achs\/journals\/content\/jnprdf\/2017\/jnprdf.2017.80.issue-4\/acs.jnatprod.7b00133\/20170424\/images\/medium\/np-2017-001334_0007.gif\" \/><\/p>\n<p align=\"justify\">Publicada no <em>Journal of Natural Products<\/em>, a pesquisa de Stierle, Stierle e seus colaboradores revelou que esses compostos s\u00e3o muito parecidos com uma classe de antibi\u00f3ticos conhecida como macrol\u00eddeos. Ao observar o funcionamento de uma dessas subst\u00e2ncias \u2014 batizada como berkeleylactona-A \u2014, os cientistas perceberam que ela atacava algumas bact\u00e9rias bem perigosas de uma maneira in\u00e9dita.<\/p>\n<p align=\"justify\">Segundo o <em>paper<\/em>, os \u201cestudos do modo de a\u00e7\u00e3o mostraram que, diferente de outros antibi\u00f3ticos macrol\u00eddeos, a berkeleylactona-A n\u00e3o inibe a s\u00edntese de prote\u00ednas nem ataca o ribossomo, o que sugere um novo modo de a\u00e7\u00e3o\u201d para a atividade do futuro medicamento. Diferente de outros macrol\u00eddeos, descobriram que a estrutura da berkeleylactona-A n\u00e3o tem um par de a\u00e7\u00facares nem uma liga\u00e7\u00e3o dupla.<\/p>\n<p align=\"justify\">Pode parecer uma mudan\u00e7a sutil, mas foi o bastante para matar de maneira eficaz quatro linhagens de MRSA resistentes a antibi\u00f3ticos, al\u00e9m do <em>Bacillus anthracis<\/em> (causador do antrax), <em>Streptococcus pyogenis<\/em> (inflama\u00e7\u00e3o da garganta) e os fungos <em>Candida albicans<\/em> e <em>C. glabrata<\/em> (que causam infec\u00e7\u00f5es em humanos).<\/p>\n<p align=\"justify\">Essa \u00e9 uma excelente not\u00edcia num momento em que precisamos de novos antibi\u00f3ticos para evitar milh\u00f5es de mortes poss\u00edveis em caso de epidemias causadas por bact\u00e9rias super-resistentes. Por\u00e9m \u2014 sempre tem um por\u00e9m \u2014 as causas da efic\u00e1cia da berkeleylactona-A continuam desconhecidas e a subst\u00e2ncia rec\u00e9m-descoberta ainda vai precisar ser testada por alguns anos antes de se tornar mais uma arma no nosso arsenal antibacteriano.<\/p>\n<h4 align=\"justify\">Refer\u00eancia<\/h4>\n<p style=\"padding-left: 30px\" align=\"justify\"><a href=\"http:\/\/scienceblogs.com.br\/hypercubic\/files\/2012\/07\/rb2_large_gray25.png\" data-rel=\"lightbox-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img decoding=\"async\" class=\"alignleft size-full wp-image-3123\" src=\"http:\/\/scienceblogs.com.br\/hypercubic\/files\/2012\/07\/rb2_large_gray25.png\" alt=\"rb2_large_gray25\" width=\"70\" height=\"85\" \/><\/a>STIERLE, Andrea A.<em> et. al.<\/em> <strong>The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture<\/strong> [<strong><em>Berkeleylactonas: antibi\u00f3ticos macrol\u00eddeos a partir de co-cultura fungal<\/em><\/strong>]. <cite>J. Nat. Prod.<\/cite>, 2017, 80 (4), pp 1150\u20131160 DOI: <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.jnatprod.7b00133\">10.1021\/acs.jnatprod.7b00133<\/a><\/p>\n<p align=\"justify\">[via <a href=\"https:\/\/sciencealert.com\/fungi-found-in-a-toxic-mine-pit-have-teamed-up-to-produce-a-new-type-of-antibiotic\">Science Alert<\/a>]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>H\u00e1 males que v\u00eam para o bem mas que bem poderia vir de um mal t\u00e3o grande quanto um lago t\u00f3xico numa mina abandonada? Resposta: novos e potentes antibi\u00f3ticos. Berkeley Pit \u00e9 uma mina de cobre a c\u00e9u aberto situada no interior de Montana, nos Estados Unidos. Abandonada desde 1982, a mina deu lugar a [&hellip;]<\/p>\n","protected":false},"author":486,"featured_media":9253,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_monsterinsights_skip_tracking":false,"material-hide-sections":[],"pgc_sgb_lightbox_settings":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"categories":[35,53,86,121,277],"tags":[550,605,683,1506,1639,2153,2345,2733,3306],"class_list":["post-9248","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioquimica-biologia","category-ciencia","category-divulgacao-cientifica","category-farmacologia","category-quimica","tag-antibioticos","tag-arsenico","tag-bacterias","tag-extremofilos","tag-fungo","tag-macrolideos","tag-mrsa","tag-poluicao","tag-toxicologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>O lado bom do lago t\u00f3xico - 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