{"id":9965,"date":"2018-04-11T20:40:33","date_gmt":"2018-04-11T23:40:33","guid":{"rendered":"http:\/\/scienceblogs.com.br\/hypercubic\/?p=9965"},"modified":"2018-04-11T20:40:33","modified_gmt":"2018-04-11T23:40:33","slug":"cincia-almiscarada","status":"publish","type":"post","link":"https:\/\/www.blogs.unicamp.br\/hypercubic\/2018\/04\/cincia-almiscarada\/","title":{"rendered":"Ci\u00eancia almiscarada"},"content":{"rendered":"<p align=\"justify\"><a href=\"http:\/\/scienceblogs.com.br\/hypercubic\/files\/2018\/04\/perfume.jpg\" data-rel=\"lightbox-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter\" style=\"border: 0px currentcolor;margin-right: auto;margin-left: auto;float: none\" title=\"perfume\" src=\"http:\/\/scienceblogs.com.br\/hypercubic\/files\/2018\/04\/perfume_thumb.jpg\" alt=\"perfume\" width=\"800\" height=\"480\" border=\"0\" \/><\/a><\/p>\n<h5 align=\"justify\">Ponto fraco dos sentidos humanos, o olfato continua intrigando cientistas. Dessa vez, eles descobriram os mecanismos por tr\u00e1s do aroma almiscarado.<\/h5>\n<p align=\"justify\">Associado ao lend\u00e1rio boi-almiscarado das montanhas tibetanas, o alm\u00edscar \u00e9 um odor comum no reino animal do Hemisf\u00e9rio Norte. Na \u00c1sia existem o cervo-almiscarado, o rato-almiscarado e at\u00e9 a ratazana-almiscarada. Na Am\u00e9rica do Norte, h\u00e1 o rato-almiscarado, o musaranho-almiscarado, o escaravelho-almiscarado e at\u00e9 o alig\u00e1tor-almiscarado. Nem as plantas escapam: existem madeiras e hibiscos com odores de alm\u00edscar.<\/p>\n<p align=\"justify\">Naturalmente, n\u00f3s tamb\u00e9m fomos seduzidos por esse odor intenso e duradouro. Extra\u00eddo das gl\u00e2ndulas genitais dos cervos-almiscarados, essa subst\u00e2ncia era (e continua a ser) usada na fabrica\u00e7\u00e3o de perfumes. Esses e os outros animais almiscarados s\u00f3 n\u00e3o foram extintos gra\u00e7as ao surgimento do alm\u00edscar sint\u00e9tico no fim do s\u00e9culo XIX.<\/p>\n<p align=\"justify\">Dada sua onipresen\u00e7a no mundo animal, estudar o alm\u00edscar e sua capta\u00e7\u00e3o pelo sistema olfativo n\u00e3o \u00e9 uma tarefa sup\u00e9rflua. Nos \u00faltimos anos, t\u00eam crescido o interesse da comunidade cient\u00edfica pela qu\u00edmica do olfato. Um dos principais grupos de pesquisa dessa \u00e1rea \u00e9 o liderado por Victor Batista, professor de qu\u00edmica da Universidade Yale (EUA).<\/p>\n<p align=\"justify\">Para entender como cheiramos o alm\u00edscar, os cientistas tiveram que identificar os receptores olfativos dessa subst\u00e2ncia em humanos. Receptores olfativos s\u00e3o como as fechaduras onde entram as chaves das subst\u00e2ncias arom\u00e1ticas. Como uma boa fechadura, receptores arom\u00e1ticos costumam ser bastante espec\u00edficos. Quando as chaves certas se encaixam neles, desencadeia-se uma s\u00e9rie de rea\u00e7\u00f5es bioqu\u00edmicas que culminam na sensa\u00e7\u00e3o do aroma de dada subst\u00e2ncia e nas mem\u00f3rias associadas a ela.<\/p>\n<p align=\"justify\">H\u00e1 alguns anos, Batista e sua equipe identificaram dois receptores olfativos em humanos: OR5AN1 e OR1A1, ambos especializados na detec\u00e7\u00e3o de aromas almiscarados. A estrutura da chave almiscarada j\u00e1 \u00e9 bem conhecida, mas a de sua fechadura n\u00e3o. Partindo de modelos computacionais, Batista <em>et. al.<\/em> conduziram experimentos com subst\u00e2ncias almiscaradas, solu\u00e7\u00f5es e prote\u00ednas.<\/p>\n<p align=\"justify\">Os resultados, rec\u00e9m-publicados online na <em>PNAS<\/em>, descrevem as estruturas desses receptores olfativos e indicam que as fechaduras do alm\u00edscar s\u00e3o mesmo especializadas. Enquanto a OR5AN1 responde a compostos macroc\u00edclicos e nitromoscados (dois grupos de alm\u00edscar sint\u00e9tico), a OR1AN1 se abre apenas com os nitromoscados. Tamb\u00e9m foram encontrados alguns amino\u00e1cidos residuais que facilitam a conex\u00e3o entre essas chaves e fechaduras arom\u00e1ticas.<\/p>\n<p align=\"justify\">Embora seja t\u00e3o inodoro quanto qualquer artigo cient\u00edfico, o <em>paper<\/em> de Batista e seus colaboradores pode nos ajudar a farejar novas descobertas em \u00e1reas t\u00e3o diversas quanto o comportamento animal, a fabrica\u00e7\u00e3o de perfumes e a farmacologia (o alm\u00edscar \u00e9 tradicionalmente usado pela medicina chinesa). \u00c9 ci\u00eancia com um toque almiscarado.<\/p>\n<p align=\"justify\">\n<h4 align=\"justify\">Refer\u00eancia<\/h4>\n<p style=\"padding-left: 30px\" align=\"justify\"><a href=\"http:\/\/scienceblogs.com.br\/hypercubic\/files\/2012\/07\/rb2_large_gray25.png\" data-rel=\"lightbox-image-1\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img decoding=\"async\" class=\"size-full wp-image-3123 alignleft\" src=\"http:\/\/scienceblogs.com.br\/hypercubic\/files\/2012\/07\/rb2_large_gray25.png\" alt=\"rb2_large_gray25\" width=\"70\" height=\"85\" \/><\/a>Lucky Ahmed <em>et al<\/em>. <strong>Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds<\/strong> [<em><strong>Mecanismo de ativa\u00e7\u00e3o molecular dos receptores humanos de alm\u00edscar OR5AN1 e OR1A1 pela (R)-muscona e v\u00e1rios outros compostos com aroma almiscarado<\/strong><\/em>] <em>PNAS<\/em>, 9 de abril de 2018. <a href=\"https:\/\/doi.org\/10.1073\/pnas.1713026115\">https:\/\/doi.org\/10.1073\/pnas.1713026115<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ponto fraco dos sentidos humanos, o olfato continua intrigando cientistas. Dessa vez, eles descobriram os mecanismos por tr\u00e1s do aroma almiscarado. Associado ao lend\u00e1rio boi-almiscarado das montanhas tibetanas, o alm\u00edscar \u00e9 um odor comum no reino animal do Hemisf\u00e9rio Norte. Na \u00c1sia existem o cervo-almiscarado, o rato-almiscarado e at\u00e9 a ratazana-almiscarada. Na Am\u00e9rica do Norte, [&hellip;]<\/p>\n","protected":false},"author":486,"featured_media":9968,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_monsterinsights_skip_tracking":false,"material-hide-sections":[],"pgc_sgb_lightbox_settings":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"categories":[35,53,86,277],"tags":[470,597,2494,2647,2866,3180],"class_list":["post-9965","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioquimica-biologia","category-ciencia","category-divulgacao-cientifica","category-quimica","tag-almiscar","tag-aromas","tag-olfato","tag-perfume","tag-receptores-olfativos","tag-substancias-aromaticas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ci\u00eancia almiscarada - hypercubic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.blogs.unicamp.br\/hypercubic\/2018\/04\/cincia-almiscarada\/\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Renato Pincelli\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/2018\\\/04\\\/cincia-almiscarada\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/2018\\\/04\\\/cincia-almiscarada\\\/\"},\"author\":{\"name\":\"Renato Pincelli\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/#\\\/schema\\\/person\\\/c7be1e2811d061a75d3b4f4960eb53bd\"},\"headline\":\"Ci\u00eancia almiscarada\",\"datePublished\":\"2018-04-11T23:40:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/2018\\\/04\\\/cincia-almiscarada\\\/\"},\"wordCount\":540,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/2018\\\/04\\\/cincia-almiscarada\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/wp-content\\\/uploads\\\/sites\\\/249\\\/2018\\\/04\\\/perfume_thumb-1.jpg\",\"keywords\":[\"alm\u00edscar\",\"aromas\",\"olfato\",\"perfume\",\"receptores olfativos\",\"subst\u00e2ncias arom\u00e1ticas\"],\"articleSection\":[\"bioqu\u00edmica\",\"ci\u00eancia\",\"divulga\u00e7\u00e3o cient\u00edfica\",\"qu\u00edmica\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/2018\\\/04\\\/cincia-almiscarada\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/2018\\\/04\\\/cincia-almiscarada\\\/\",\"url\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/hypercubic\\\/2018\\\/04\\\/cincia-almiscarada\\\/\",\"name\":\"Ci\u00eancia almiscarada - 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