{"id":3453,"date":"2023-09-12T11:13:20","date_gmt":"2023-09-12T14:13:20","guid":{"rendered":"https:\/\/www.blogs.unicamp.br\/quimikinha\/?p=3453"},"modified":"2023-09-12T23:08:02","modified_gmt":"2023-09-13T02:08:02","slug":"mutagenese-do-dna-a-partir-do-cloreto-de-vinila","status":"publish","type":"post","link":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/","title":{"rendered":"Mutag\u00eanese do DNA a partir do cloreto de vinila"},"content":{"rendered":"\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Na postagem anterior intitulada “Cloreto de vinila \u2013 explos\u00e3o em forma de mol\u00e9cula?<\/a>“, n\u00f3s conversamos sobre a explos\u00e3o que foi causada pelas m\u00e1s condi\u00e7\u00f5es de transporte do cloreto de vinila em Ohio nos EUA. <\/span>O composto \u00e9 um c\u00e2ncerigeno j\u00e1 conhecido, e seu principal modo de a\u00e7\u00e3o em termos de causar c\u00e2ncer envolve sua ativa\u00e7\u00e3o metab\u00f3lica dentro da c\u00e9lula. <\/span><\/p>\n

Os produtos qu\u00edmicos que tem a capacidade de se ligar ao DNA e induzem muta\u00e7\u00f5es s\u00e3o conhecidos como mutag\u00eanicos. No entanto, a<\/span>o considerar a intera\u00e7\u00e3o qu\u00edmica do cloreto de vinila com o DNA, \u00e9 importante deixar claro desde j\u00e1 que o cloreto de vinila n\u00e3o se liga quimicamente ao DNA de maneira direta. Sendo assim, como o<\/span> o cloreto de vinila desencadeia as rea\u00e7\u00f5es que s\u00e3o capazes de modificar o DNA?  Vamos juntos conversar um pouquinho sobre isso nessa postagem do Blog Quimikinha!<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Como o cloreto de vinila causa c\u00e2ncer?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Sabe-se que a<\/span>\u00a0exposi\u00e7\u00e3o ao cloreto de vinila por ingest\u00e3o, inala\u00e7\u00e3o ou contato com a pele pode levar \u00e0 sua absor\u00e7\u00e3o pela corrente sangu\u00ednea, de onde \u00e9 transportado para o f\u00edgado.\u00a0<\/span>O cloreto de vinila sofre metabolismo enzim\u00e1tico no f\u00edgado, principalmente pela enzima citocromo P450 2E1 (CYP2E1), para formar um intermedi\u00e1rio chamado 2-cloro-oxirano ou \u00f3xido de cloroetileno, um ep\u00f3xido tal apresentado na Figura 1.\u00a0<\/span><\/p>

<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t
Figura 1. Mecanismo de mutag\u00eanese do DNA a partir do cloreto de vinila: uma vez que o cloreto de vinila \u00e9 transportado para o f\u00edgado, a enzima citocromo P450 o converte no ep\u00f3xido, que \u00e9 altamente reativo com as bases no DNA (guanina, por exemplo) e, dessa maneira modifica o DNA levando a uma forma\u00e7\u00e3o de \"adutos de DNA\".<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

A mol\u00e9cula c\u00edclica formada a partir do cloreto de vinila cont\u00e9m um grupo ep\u00f3xido (o anel c\u00edclico altamente reativo que contem tr\u00eas \u00e1tomos – 2 carbonos e um oxig\u00eanio) que pode se ligar facilmente \u00e0s bases do DNA dentro da c\u00e9lula humana, resultando na forma\u00e7\u00e3o de adutos de DNA. Esses compostos formados, por sua vez, podem causar as muta\u00e7\u00f5es no DNA que s\u00e3o respons\u00e1veis pelo desenvolvimento de c\u00e2ncer.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Para saber mais:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Guengerich, F. P., & Ghodke, P. P. (2021). Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides. Genes and Environment, 43(1), 24. https:\/\/doi.org\/10.1186\/s41021-021-00199-x<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Na postagem anterior intitulada “Cloreto de vinila \u2013 explos\u00e3o em forma de mol\u00e9cula?“, n\u00f3s conversamos sobre a explos\u00e3o que foi causada pelas m\u00e1s condi\u00e7\u00f5es de transporte […]<\/a><\/p>\n<\/div>","protected":false},"author":110,"featured_media":3495,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_eb_attr":"","_monsterinsights_skip_tracking":false,"pgc_sgb_lightbox_settings":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"categories":[72,71,73,75,1],"tags":[92],"class_list":["post-3453","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-acidente","category-desastre-ambiental","category-dna","category-figado","category-sem-categoria","tag-cancer"],"yoast_head":"\nMutag\u00eanese do DNA a partir do cloreto de vinila - Quimikinha<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mutag\u00eanese do DNA a partir do cloreto de vinila - Quimikinha\" \/>\n<meta property=\"og:description\" content=\"Na postagem anterior intitulada “Cloreto de vinila \u2013 explos\u00e3o em forma de mol\u00e9cula?“, n\u00f3s conversamos sobre a explos\u00e3o que foi causada pelas m\u00e1s condi\u00e7\u00f5es de transporte [...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/\" \/>\n<meta property=\"og:site_name\" content=\"Quimikinha\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/gihchemistry\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-12T14:13:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-13T02:08:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2023\/09\/1111.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1305\" \/>\n\t<meta property=\"og:image:height\" content=\"894\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Gisele Silvestre\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@gihchemistry\" \/>\n<meta name=\"twitter:site\" content=\"@gihchemistry\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gisele Silvestre\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/\"},\"author\":{\"name\":\"Gisele Silvestre\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/#\\\/schema\\\/person\\\/1fd6f5a6c7f0dd25fe54201ab84a3d27\"},\"headline\":\"Mutag\u00eanese do DNA a partir do cloreto de vinila\",\"datePublished\":\"2023-09-12T14:13:20+00:00\",\"dateModified\":\"2023-09-13T02:08:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/\"},\"wordCount\":503,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/wp-content\\\/uploads\\\/sites\\\/86\\\/2023\\\/09\\\/1111.png\",\"keywords\":[\"C\u00e2ncer\"],\"articleSection\":[\"Acidente\",\"Desastre ambiental\",\"DNA\",\"Figado\",\"Qu\u00edmikinha - Qu\u00edmica e biomol\u00e9culas\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/\",\"url\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/\",\"name\":\"Mutag\u00eanese do DNA a partir do cloreto de vinila - Quimikinha\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/wp-content\\\/uploads\\\/sites\\\/86\\\/2023\\\/09\\\/1111.png\",\"datePublished\":\"2023-09-12T14:13:20+00:00\",\"dateModified\":\"2023-09-13T02:08:02+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/#\\\/schema\\\/person\\\/1fd6f5a6c7f0dd25fe54201ab84a3d27\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/wp-content\\\/uploads\\\/sites\\\/86\\\/2023\\\/09\\\/1111.png\",\"contentUrl\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/wp-content\\\/uploads\\\/sites\\\/86\\\/2023\\\/09\\\/1111.png\",\"width\":1305,\"height\":894},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/2023\\\/09\\\/12\\\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mutag\u00eanese do DNA a partir do cloreto de vinila\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/#website\",\"url\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/\",\"name\":\"Quimikinha\",\"description\":\"site Blogs Cient\u00edficos - UNICAMP sites\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/#\\\/schema\\\/person\\\/1fd6f5a6c7f0dd25fe54201ab84a3d27\",\"name\":\"Gisele Silvestre\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/wp-content\\\/uploads\\\/sites\\\/86\\\/2016\\\/05\\\/IMG_20160703_194115.jpg\",\"url\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/wp-content\\\/uploads\\\/sites\\\/86\\\/2016\\\/05\\\/IMG_20160703_194115.jpg\",\"contentUrl\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/wp-content\\\/uploads\\\/sites\\\/86\\\/2016\\\/05\\\/IMG_20160703_194115.jpg\",\"caption\":\"Gisele Silvestre\"},\"description\":\"Atualmente, sou pesquisadora na \u00e1rea de inova\u00e7\u00e3o tecnol\u00f3gica no Laborat\u00f3rio Multiusu\u00e1rio de Qu\u00edmica e Produtos Naturais sediado na Embrapa - CE (Postdoc). Doutora em Qu\u00edmica pela Unicamp (2017). Bacharel em qu\u00edmica pela Universidade Federal do Cear\u00e1 (2011). Interessada na populariza\u00e7\u00e3o da ci\u00eancia, parcerias, trocas de conhecimentos cient\u00edficos e culturais. Tenho como hobby o ato de \\\"aprender\\\" . O conhecimento sempre me surpreende e fascina. Minha miss\u00e3o \u00e9 compartilhar conhecimento e descobertas cient\u00edficas. Ci\u00eancia para todos! Carpe Diem!\",\"sameAs\":[\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/blog\\\/\",\"https:\\\/\\\/www.facebook.com\\\/gihchemistry\",\"https:\\\/\\\/www.instagram.com\\\/gihchemistry\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/in\\\/giselesilvestre\\\/\",\"https:\\\/\\\/x.com\\\/gihchemistry\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UC3_MeOnX0CW4XQ8FNbltkug\"],\"url\":\"https:\\\/\\\/www.blogs.unicamp.br\\\/quimikinha\\\/author\\\/gihchemistry\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mutag\u00eanese do DNA a partir do cloreto de vinila - Quimikinha","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/","og_locale":"pt_BR","og_type":"article","og_title":"Mutag\u00eanese do DNA a partir do cloreto de vinila - Quimikinha","og_description":"Na postagem anterior intitulada “Cloreto de vinila \u2013 explos\u00e3o em forma de mol\u00e9cula?“, n\u00f3s conversamos sobre a explos\u00e3o que foi causada pelas m\u00e1s condi\u00e7\u00f5es de transporte [...]","og_url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/","og_site_name":"Quimikinha","article_author":"https:\/\/www.facebook.com\/gihchemistry","article_published_time":"2023-09-12T14:13:20+00:00","article_modified_time":"2023-09-13T02:08:02+00:00","og_image":[{"width":1305,"height":894,"url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2023\/09\/1111.png","type":"image\/png"}],"author":"Gisele Silvestre","twitter_card":"summary_large_image","twitter_creator":"@gihchemistry","twitter_site":"@gihchemistry","twitter_misc":{"Escrito por":"Gisele Silvestre","Est. tempo de leitura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#article","isPartOf":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/"},"author":{"name":"Gisele Silvestre","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/#\/schema\/person\/1fd6f5a6c7f0dd25fe54201ab84a3d27"},"headline":"Mutag\u00eanese do DNA a partir do cloreto de vinila","datePublished":"2023-09-12T14:13:20+00:00","dateModified":"2023-09-13T02:08:02+00:00","mainEntityOfPage":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/"},"wordCount":503,"commentCount":0,"image":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#primaryimage"},"thumbnailUrl":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2023\/09\/1111.png","keywords":["C\u00e2ncer"],"articleSection":["Acidente","Desastre ambiental","DNA","Figado","Qu\u00edmikinha - Qu\u00edmica e biomol\u00e9culas"],"inLanguage":"pt-BR","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/","url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/","name":"Mutag\u00eanese do DNA a partir do cloreto de vinila - Quimikinha","isPartOf":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#primaryimage"},"image":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#primaryimage"},"thumbnailUrl":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2023\/09\/1111.png","datePublished":"2023-09-12T14:13:20+00:00","dateModified":"2023-09-13T02:08:02+00:00","author":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/#\/schema\/person\/1fd6f5a6c7f0dd25fe54201ab84a3d27"},"breadcrumb":{"@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/"]}]},{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#primaryimage","url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2023\/09\/1111.png","contentUrl":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2023\/09\/1111.png","width":1305,"height":894},{"@type":"BreadcrumbList","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/2023\/09\/12\/mutagenese-do-dna-a-partir-do-cloreto-de-vinila\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/www.blogs.unicamp.br\/quimikinha\/"},{"@type":"ListItem","position":2,"name":"Mutag\u00eanese do DNA a partir do cloreto de vinila"}]},{"@type":"WebSite","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/#website","url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/","name":"Quimikinha","description":"site Blogs Cient\u00edficos - UNICAMP sites","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.blogs.unicamp.br\/quimikinha\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":"Person","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/#\/schema\/person\/1fd6f5a6c7f0dd25fe54201ab84a3d27","name":"Gisele Silvestre","image":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2016\/05\/IMG_20160703_194115.jpg","url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2016\/05\/IMG_20160703_194115.jpg","contentUrl":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2016\/05\/IMG_20160703_194115.jpg","caption":"Gisele Silvestre"},"description":"Atualmente, sou pesquisadora na \u00e1rea de inova\u00e7\u00e3o tecnol\u00f3gica no Laborat\u00f3rio Multiusu\u00e1rio de Qu\u00edmica e Produtos Naturais sediado na Embrapa - CE (Postdoc). Doutora em Qu\u00edmica pela Unicamp (2017). Bacharel em qu\u00edmica pela Universidade Federal do Cear\u00e1 (2011). Interessada na populariza\u00e7\u00e3o da ci\u00eancia, parcerias, trocas de conhecimentos cient\u00edficos e culturais. Tenho como hobby o ato de \"aprender\" . O conhecimento sempre me surpreende e fascina. Minha miss\u00e3o \u00e9 compartilhar conhecimento e descobertas cient\u00edficas. Ci\u00eancia para todos! Carpe Diem!","sameAs":["https:\/\/www.blogs.unicamp.br\/quimikinha\/blog\/","https:\/\/www.facebook.com\/gihchemistry","https:\/\/www.instagram.com\/gihchemistry\/","https:\/\/www.linkedin.com\/in\/giselesilvestre\/","https:\/\/x.com\/gihchemistry","https:\/\/www.youtube.com\/channel\/UC3_MeOnX0CW4XQ8FNbltkug"],"url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/author\/gihchemistry\/"}]}},"jetpack_featured_media_url":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-content\/uploads\/sites\/86\/2023\/09\/1111.png","_links":{"self":[{"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/posts\/3453","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/users\/110"}],"replies":[{"embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/comments?post=3453"}],"version-history":[{"count":57,"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/posts\/3453\/revisions"}],"predecessor-version":[{"id":3527,"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/posts\/3453\/revisions\/3527"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/media\/3495"}],"wp:attachment":[{"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/media?parent=3453"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/categories?post=3453"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.blogs.unicamp.br\/quimikinha\/wp-json\/wp\/v2\/tags?post=3453"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}